About
the Cancer
Macroenvironment
Lab
The Cancer Macroenvironment Lab is a research laboratory led by Jose M. Adrover at the Francis Crick Institute in London.
We study how cancer affects the entire body, with an emphasis on blood cell formation and the cardiovascular and immune systems.
Cancer is a highly complex disease, and tumour progression requires the concerted action (and inaction) of many physiological systems. To survive, tumours co-opt and modify many different biological processes. This can happen both locally in the tumour’s immediate area, its ‘microenvironment’, and more widely across the whole organism, its ‘macroenvironment.’ In doing so, cancer affects normal physiology in ways that can be detrimental and often fatal.
For example, cancer patients have an increased risk of developing cardiovascular diseases, but we still don’t fully understand how this takes place.
Tumours can also hijack the production of blood cells in our body, leading to the production of cells that are more favourable to the tumour’s growth. It can also change the way some immune cells behave, including neutrophils, which are the most abundant immune cell in human blood.
By better understanding these processes, we hope to find ways of protecting cancer patients and cancer survivors from some of the adverse effects associated with tumours.
Areas
of interest
We study how cancer affects whole-body physiology to find ways to help cancer and cardiovascular disease patients.
The lab focuses on three main areas of research:
- Cancer-cardiovascular disease interplay
- Cancer-haematopoiesis interplay
- Cancer-innate immunity interplay
Lab
publications
Here you can find the publications from our lab.
The
Cancer
Macro
environment
Lab
is led by Jose M. Adrover and located at the Francis Crick Institute in central London.
Contact
the Cancer
Macroenvironment Lab
Here you can send us queries, questions, or comments.
Fill out the form below and we’ll get in touch with you as soon as possible.
Alternatively, feel free to email us here.
